Matrine 苦参碱

规格: 98%
CAS: 519-02-8
产品编号: H99762
MDL: MFCD00210527
品牌: INFI
Chemical NameMatrine
CAS Number519-02-8
MDL NumberMFCD00210527
Synonym (+)-MATRINE 2-羟基-4-甲氧基苯乙酮 26-4105 Alkaloids Sophora Flavescen MASSMARK 1621 MATRENE MATRIDIN-15-ONE MATRINE MATRINE(P) MATRINE, 98.0% BY HPLC MATRINIUM Matridin-15-one Sophocarpidine Matridin-15-one, Sophocarpidine Matrine Matrines PAEONOL SOPHOCARPIDINE alpha-Matrine alpha-matrine 丹皮酚 苦参碱 苦參鹼
Merck Number5759
Chemical Name Translation苦参碱
EC Number209-012-2
Beilstein Registry Number85851
LabNetwork Molecule IDLN00235752
Reaxys-RN85851
PubChem Substance ID125307543
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTYAD8 Zhongcaoyao.  Chinese Traditional and Herbal Medicine.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11-
      1980-  Volume(issue)/page/year: 18,214,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 74150 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China
   International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24-
   1989-  Volume(issue)/page/year: 27,201,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CPBTAL Chemical and Pharmaceutical Bulletin.  (Japan Pub. Trading Co., USA,
   1255 Howard St., San Francisco, CA 94103)  V.6-    1958-
   Volume(issue)/page/year: 18,2555,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 64850 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China
   International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24-
   1989-  Volume(issue)/page/year: 27,201,1992

WGK Germany3
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P312
  • P305+P351+P338
  • P330 Rinse mouth. 漱口
  • P337+P313
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
    Hazard statements
    • H302 Harmful if swallowed 吞食有害
    • H319 Causes serious eye irritation 严重刺激眼睛
      RTECSOQ1754000
      Signal word Warning
      Safety Statements
      • S22 Do not breathe dust 不要吸入粉尘；
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
      • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
      • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
      • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
        Hazard Codes Xn
        Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
        Risk Statements
        • R22 Harmful if swallowed 吞咽有害
          Storage condition 0-10°C 贮存温度2-8℃
        • 抗菌消炎药，用于慢性宫颈炎、菌痢、肠炎等
        • {MCE} [2]. Tan C, et al. Matrine induction of reactive oxygen species activates p38 leading to caspase-dependent cell apoptosis in non-small cell lung cancer cells. Oncol Rep. 2013 Nov;30(5):2529-35.
        • {MCE} [3]. Li X, et al. Regulation of endothelial nitric oxide synthase and asymmetric dimethylarginine by matrine attenuates isoproterenol-induced acute myocardial injury in rats. J Pharm Pharmacol. 2012 Aug;64(8):1107-18.
        • {MCE} [4]. Zhang B, et al. Antiinflammatory effects of matrine in LPS-induced acute lung injury in mice. Eur J Pharm Sci. 2011 Dec 18;44(5):573-9.
        • {ALD} Beilstein:24(2)58
        • {MCE} [1]. Luo C, et al. Inhibition of matrine against gastric cancer cell line MNK45 growth and its anti-tumor mechanism. Mol Biol Rep. 2012 May;39(5):5459-64.
        • {MCE} [1]. Luo C, et al. Inhibition of matrine against gastric cancer cell line MNK45 growth and its anti-tumor mechanism. Mol Biol Rep. 2012 May;39(5):5459-64.
        • {MCE} [2]. Tan C, et al. Matrine induction of reactive oxygen spe
          • 519-02-8 H99762 Matrine 苦参碱

          化学属性

          Mol. FormulaC15H24N2O
          Mol. Weight248
          Density1.16
          Melting Point76
          Boiling Point223°C/6mmHg(lit.)
          Refractive index1,536

          *以上化合物性质及应用等信息仅供参考