SAHA 伏立诺他

规格: 99%
CAS: 149647-78-9
产品编号: H96827
MDL: MFCD00945317
品牌: INFI
Chemical NameN-Hydroxy-N'-phenyloctanediamide
Synonym MK-0683, MK 0683, MK0683, SAHA, M344, CCRIS 8456, HSDB 7930, Vorinostat, suberoylanilide hydroxamic acid, Zolinza N-Hydroxy-N'-phenyloctanediamide N-hydroxy-N'-phenyl-octanediamide Suberoylanilide hydroxamic acid Vorinostat SAHA
MDL NumberMFCD00945317
CAS Number149647-78-9
Reaxys-RN7213017
PubChem Substance ID160871381
Merck Number10034
Chemical Name TranslationN-羟基-N'-苯基辛二酰胺
Beilstein Registry Number7213017
FormulaC14H20N2O3
IUPAC NameN1-hydroxy-N8-phenyloctanediamide
InChIKeyWAEXFXRVDQXREF-UHFFFAOYSA-N
InChIInChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
Canonical SMILESO=C(NO)CCCCCCC(NC1=CC=CC=C1)=O
GHS Symbol
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
    Precautionary statements
    • P201 Obtain special instructions before use. 使用前获取专门指示。
    • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
    • P308+P313
    • P405 Store locked up. 上锁保管。
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Hazard statements
      • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
      • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
      • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
        WGK Germany3
        Signal word Danger
        Hazard Codes T
        Risk Statements
        • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
        • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
          RTECSRG8835000
          Storage condition -20 -20°C Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
        • Vorinostat, also known as suberanilohydroxamic acid, MK-0683 and SAHA, is a potent and selective inhibitor of histone deacetylases (HDACs). Vorinostat has been shown to bind to the active site of histone deacetylases and act as a chelator for Zinc ions also found in the active site of histone deacetylases. Vorinostat's inhibition of histone deacetylases results in the accumulation of acetylated histones and acetylated proteins, including transcription factors crucial for the expression of genes needed to induce cell differentiation. Vorinostat was approved for the treatment of cutaneous T cell lymphoma (CTCL) when the disease persists, gets worse, or comes back during or after treatment with other medicines.
          • 149647-78-9 H96827 SAHA 伏立诺他

          化学属性

          Mol. FormulaC14H20N2O3
          Mol. Weight264
          Melting Point161-162
          Density1.2
          Appearance White to off-white solid powder
          SolubilitySoluble in DMSO, not in water

          *以上化合物性质及应用等信息仅供参考