包装 价格 库存 - 促销价
100mL    RMB    70
500mL    RMB   150
1L       RMB   240
N,N-Dimethylformamide	N,N-二甲基甲酰胺

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  • Mol. Formula: C3H7NO
  • Mol. Weight: 73.10
  • Refractive index: 1.4280 to 1.4320
  • Boiling Point: 153
  • Density: 0.948
  • Melting Point: -61
  • Flash Point: 60°C(lit.)
  • TSCA: Yes
  • Autoignition Point: 833 °F
  • Vapor Density: 2.5 (vs air)
  • Vapor Pressure: 2.7 mmHg ( 20 °C)
  • Solubility: 可溶
  • Stability: 对湿度敏感
Chemical NameN,N-Dimethylformamide
Synonym
  • 二甲基甲酰胺
  • NSC 5356
  • DMF
  • amide,n,n-dimethyl-formicaci
  • dimethylformamide (DMF)
  • DMF NSC 5356
  • DMF (Amide)
  • NCI-C60913
  • N,N-二甲基甲酰胺
  • 二甲基甲醯胺 098-01 [3]
  • N,N-二甲基甲酰胺, HPLC GRADE, 99.7+%, PACKAGED UNDER ARGON
  • N,N-二甲基甲酰胺
  • N,N-dimethylformamide
  • 甲酰二甲胺
  • N.N-二甲基甲酰胺
  • 二甲基甲酰胺;甲酰二甲胺;N-甲酰二甲胺;二甲替甲酰胺;DMFA;DMF
  • N,N-二甲基甲酰胺, ANHYDROUS, AMINE FREE, 99.9%
  • dlmethylformamide
  • N',N-DIMETHYLFORMAMIDE
  • FORMIC ACID DIMETHYLAMIDE
  • N-甲酰二甲胺
  • FORMYLDIMETHYLAMINE
  • FORMDIMETHYLAMIDE
  • Dimetilformamide
  • N,N-DIMETHYLFORMAMIDE
  • Dimethylformamid
  • DMF(N,N-二甲基甲酰胺)
  • DIMETHYLFORMAMIDE
  • N-Formyldimethylamine
  • Dimethyl formamide; Formyldimethylamine; DMF; DMFA
  • DMFA
  • N,N-Dimethyl-formamide
  • dimetylformamidu(czech)
  • LEDA HPLC二甲基甲酰胺
  • 二甲基甲酰胺,甲酰二甲胺,N-甲酰二甲胺,二甲替甲酰胺,N.N-二甲基甲酰胺
  • Dimethylforamide
  • N,N-二甲基甲酰胺, ANHYDROUS, 99.8%, PACKAGED UNDER ARGON I
  • dimethylamidkyselinymravenci(czech)
  • Dimethylformamide
  • U-4224
  • N
  • N,N-dimethylmethanamide
  • Dwumetyloformamid
CAS Number68-12-2
PubChem Substance ID 87567359
EC Number200-679-5
Beilstein Registry Number605365
MDL NumberMFCD00003284
Reaxys-RN605365
Merck Number3243
Chemical Name TranslationN,N-二甲基甲酰胺
Wiswesser Line NotationVHN1&1
GHS Symbol
WGK Germany1
Hazard Codes
  • T
Hazard statements
  • H312+332
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H226 Flammable liquid and vapour 易燃液体和蒸气
Personal Protective Equipment
  • Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSLQ2100000
Precautionary statements
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P301+312+330
  • P403+233 Store in a well-ventilated place. Keep container tightly closed. 存放在通风良好的地方。保持容器密闭。
  • P305+351+338+310
  • P303+361+353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. 如果沾上皮肤(或头发):删除/立即脱掉所有被污染的衣服。清洗/淋浴冲洗皮肤。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P304+340+311
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P308+311
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P308+313 IF exposed or concerned: Get medical advice/attention. 如接触到或有疑虑:求医/就诊。
  • P370+378 In case of fire: Use … for extinction. 如果发生火灾:使用...灭火。
  • P241+242+243
  • P201280305+351+338308+313
  • P405 Store locked up. 上锁保管。
Signal word
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
Risk Statements
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
  • R20/21 Harmful by inhalation and in contact with skin 吸入及与皮肤接触有害
  • R36 Irritating to eyes 刺激眼睛
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
UN Number
  • UN2265
Storage condition
  • Store at RT.
  • 充氩保存。
  • 密封保存。
  • Hygroscopic
Packing GroupIII
Hazard Class3
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Liver - other changes
   Kidney, Ureter, Bladder - other changes in urine composition
   Blood - changes in cell count (unspecified)
REFERENCE :
   BJIMAG British Journal of Industrial Medicine.  (British Medical Journal,
   Box 560B, Kennebunkport, ME 04046)  V.1-    1944-  Volume(issue)/page/year:
   13,51,1956

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 470 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 15,618,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3700 mg/kg
TOXIC EFFECTS :
   Behavioral - somnol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 650 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CNCRA6 Cancer Chemotherapy Reports.  (Bethesda, MD)  V.1-52, 1959-68.  For
   publisher information, see CTRRDO.  Volume(issue)/page/year: 30,9,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 1050 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Human
DOSE/DURATION           : 12300 ug/m3/Y
REFERENCE :
   ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete.  (VEB
   Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
   Rep.)  V.1-    1955-  Volume(issue)/page/year: 31,366,1985

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 300 mg/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,502,1981

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 25 mg/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,468,1981

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 500 ug/kg/24H
REFERENCE :
   DOYADI Dongwuxue Yanjiu.  Zoological Research.  (China International Book
   Trading Corp., POB 2820, Beijing, Peop. Rep. China)  V.1-    1980-
   Volume(issue)/page/year: 8,27,1987

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 600 ug/plate
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,343,1981

TYPE OF TEST            : Host-mediated assay
TEST SYSTEM             : Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2100 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   DEGEA3 Deutsche Gesundheitswesen.  (VEB Verlag Volk und Gesundheit, Neue
   Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1946-
   Volume(issue)/page/year: 30,455,1975

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TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5030 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 5200 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:

  • 许多疏水化合物的溶剂。非水溶液滴定用试剂,乙烯树脂和乙炔的溶剂,有机合成,光度测定,气相色谱固定液(最高使用温度50℃,溶剂为甲醇),分离分析C2-C5烃,并能分离正、异丁烯-[1]及顺、反丁烯-[2]。农药残留量分析。有机合成。肽的合成。照相工业用。
  • In combination with POCl3, (COCl)2, etc., generates an iminium chloride intermediate for the formylation of reactive aromatic nuclei by the Vilsmeier reaction:
  • CAUTION! Thermal runaway reactions can occur with NaH; see Sodium hydride, 13431.
  • In aqueous DMF, tosylate esters undergo formolysis to formate esters: Synth. Commun., 26, 1031 (1996).
  • Vilsmeier conditions also promote dehydrations, e.g. in cyclodehydration of hydroxyphenols to give cyclic ethers, as an efficient alternative to the Mitsunobu reaction: J. Chem. Soc., Perkin 1, 2249 (1996); J. Org. Chem., 59, 4346 (1994):
  • Dipolar aprotic solvent, in which anions have enhanced nucleophilicity, compare Dimethyl­ sulfoxide, A13280. Effective solvent for a vast range of reactions.
  • Merck: 14,3243 Beilstein: 4,IV,171
  • Compare also N-Methyl­formanilide, A11829, and preformed Vilsmeier reagent (Chloromethyl­ene)­dimethyl­ammonium chloride, B24172. Monograph: Synthesis Using Vilsmeier Reagents, C. M. Marson, P. R. Giles, CRC Press, Boca Raton, FL (1994). Formylation can be extended to less active substrates, e.g. acenaphthene or mesitylene, with the DMF-triflic anhydride reagent: J. Chem. Soc., Chem. Commun., 1571 (1990). Under Vilsmeier conditions, electron-rich alkenes can be converted to ɑß-unsaturated aldehydes; see, e.g.: Synthesis, 752 (1976); and ketones to ß-chloroenals: Synthesis, 496 (1985); Org. Synth. Coll., 5, 215 (1973).
  • For the free-radical formylation of perfluoroalkyl iodides, see Zinc-copper couple, L09811.
  • Vilsmeier conditi
  • Merck: 14,3243
  • DMF can also be used for formylation with alkyllithium or Grignard reagents: Synthesis, 228 (1984).
  • Vilsmeier conditions also promote dehydrations, e.g. in cyclodehydration of hydroxyphenols to give cyclic ethers, as an efficient alternati
  • 部分产品数据参考 LabNovo , 请谨慎使用并以实际实验测量值为准。