Epibromohydrin 环氧溴丙烷

规格: 97%
CAS: 3132-64-7
产品编号: H74299
MDL: MFCD00005130
品牌: INFI
Chemical NameEpibromhydrin
CAS Number3132-64-7
Synonym ######## (±)-(Brommethyl)oxiran (±)-(Bromomethyl)oxirane (±)-3-Bromo-1,2-epoxypropane (±)-Epibromohydrin 1,2-Epoxy-3-bromopropane 1,2-環氧-3-溴丙烷 1-bromo-2,3-epoxy-propan 1-bromo-2,3-epoxy-propane 2-(Bromomethyl)oxirane 3-BROMOPROPYLENE OXIDE 3-Bromopropylene oxide 3-bromo-1,2-epoxy-propan 3-溴-1,2-环氧丙烷 BROMOMETHYLOXIRANE Epibromhydrin Epibromohydrin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID18430
EC Number221-525-3
Beilstein Registry Number79786
MDL Number-
Reaxys-RN79786
Chemical Name Translation环氧溴丙烷
Wiswesser Line NotationT3OTJ B1E
LabNetwork Molecule IDLN00239728
InChIInChI=1S/C3H5BrO/c4-1-3-2-5-3/h3H,1-2H2
Canonical SMILES-
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 17,145,1967

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 50 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 249,55,1991

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 231,205,1990

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 20 umol/L
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   46,277,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 172,105,1986

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Klebsiella pneumoniae
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,269,1981

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 1500 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 92,427,1982

{hazar

WGK Germany2
Hazard Codes 6.1 Xn
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H351 Suspected of causing cancer 怀疑致癌
    Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
    RTECSTX4115000
    Precautionary statements
    • P201 Obtain special instructions before use. 使用前获取专门指示。
    • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
    • P203
    • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
    • P233 Keep container tightly closed. ?保持容器密闭。
    • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
    • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
    • P242 Use only non-sparking tools. 只能使用无火花工具。
    • P243 Take precautionary measures against static discharge. 采取预防措施，防止静电放电。
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P264+P265
    • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
    • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
    • P301+P310
    • P301+P312
    • P301+P316
    • P301+P317
    • P302+P352
    • P303+P361+P353
    • P304+P340
    • P305+P351+P338
    • P305+P351+P338+P337+
    • P308+P313
    • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
    • P316
    • P318
    • P319
    • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
    • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
    • P330 Rinse mouth. 漱口
    • P332+P313
    • P332+P317
    • P337+P313
    • P337+P317
    • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
    • P361+P364
    • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
    • P362+P364
    • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
    • P370+P378
    • P403+P233
    • P403+P235
    • P405 Store locked up. 上锁保管。
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Warning {} {} {} {} {} {} {} {} {TCI}
      UN Number 2558
      Storage condition +4°C 2-8°C 4 4°C 4°C, Inert atmosphere 密封避光保存
      Packing GroupI
      Hazard Class6.1/3
      Safety Statements
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
      • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
        Risk Statements
        • R22 Harmful if swallowed 吞咽有害
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
        • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
          Warnings 危化品目录(2015)
          Restrict 危险品
        • Bromohydrin pyrophosphate enhances antibody-dependent cell-mediated cytotoxicity induced by therapeutic antibodies.
        • {uni_hamburg} Short: II/25C
        • {TRC} Weng, W., et al.: J. Clin. Oncol., 21, 3940 (2003); Shields, R., et al.: J. Biol. Chem., 277, 26733 (2002),
        • {TRC} Sicard, H., et al.: J. Immunol. 175, 5471 (2005),
        • {ALD} Beilstein:17,9
        • {uni_hamburg} Short: II/14a
          • 3132-64-7 H74299 Epibromohydrin 环氧溴丙烷

          化学属性

          Mol. FormulaC3H5BrO
          Mol. Weight136.98
          Refractive index1.4790 to 1.4840
          Boiling Point
          Density1.601
          Melting PointN/A
          Stability对光敏感
          Flash Point-
          Solubility不溶于水，溶于热乙醇、乙醚、苯、氯仿。

          *以上化合物性质及应用等信息仅供参考