Kojic acid 曲酸

规格: 98%
CAS: 501-30-4
产品编号: H72828
MDL: MFCD00006580
品牌: INFI
Chemical Name5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
Synonym Kojic acid {LY} Kojic acid {} {LY} Kojic acid {} {} {LY} Kojic acid {} {} {} {LY} Kojic acid {} {} {} {} {LY} Kojic acid {} {} {} {} {} {LY} Kojic acid {} {} {} {} {} {} {LY} Kojic acid {} {} {} {} {} {} {} {LY} Kojic acid {} {} {} {} {} {} {} {} {LY} Kojic acid {} {} {} {} {} {} {} {} {} {LY} Kojic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Kojic acid {} {} {} {} {} {} {} {} {} {} {} {LY} Kojic acid {} {} {} {} {} {} {} {} {} {} {} {} {LY} Kojic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Kojic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Kojic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Kojic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Kojic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Kojic acid {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00006580
PubChem Substance ID87571949
Beilstein Registry Number120895
CAS Number501-30-4
EC Number207-922-4
Merck Number5317
Chemical Name Translation5-羟基-2-(羟甲基)-4H-吡喃-4-酮
Reaxys-RN120895
InChIKeyBEJNERDRQOWKJM-UHFFFAOYSA-N
Wiswesser Line NotationT6O DVJ B1Q EQ
LabNetwork Molecule IDLN00195082
InChIInChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
Canonical SMILESO=C1C=C(CO)OC=C1O
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 5,393,1981

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 155,302,1945

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
   eds., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 3,1755,1978

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
   eds., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 3,1755,1978

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TYPE OF TEST            : LDLo - Lowest publ

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 2 mg/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 67,367,1979

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 4500 mg/L
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 59,213,1991

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 4500 mg/L
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 59,213,1991

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 500 ng/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 58,193,1978

GHS Symbol
WGK Germany3
RTECSUQ0875000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
    Risk Statements
    • R45 May cause cancer 可能致癌
    • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
    • R42/43
    • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
    • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
    • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
      Hazard Codes T;Xn
      Precautionary statements
      • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
        Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
      • 用作定量分析三价铁的试剂。
      • 酪氨酸酶抑制剂。曲菌酸是一种黑色素专属性抑制剂，它进入皮肤细胞后能够与细胞中的铜离子络合，改变酪氨酸酶的立体结构，阻止酪氨酸酶的活化，从而抑制黑色素的形成。存在于酿酒用的曲霉（Aspergillus）培养基中。可利用米曲霉（Aspergillus oryzae）进行好氧发酵制取。用作增香剂。
      • {SA}
      • Tamura, T., et al., Time course observation of thyroid proliferative lesions and serum levels of related hormones in rats treated with kojic acid after DHPN initiation. J. Toxicol. Sci. 24 , 145-155, (1990) 摘要
      • {SA}
      • {SA} Novotny, L., et al., Kojic acid--a new leading molecule for a preparation of compounds with an anti-neoplastic potential. Neoplasma 46 , 89-92, (1999) 摘要
      • {SA}
      • {SA} Fujimoto, N., et al., Changes in thyroid function during development of thyroid hyperplasia induced by kojic acid in F344 rats. Carcinogenesis 20 , 1567-1571, (1999) 摘要
      • {SA}
      • {SA} Merck 14 ,5317
      • {SA}
      • Beil. 18 ,V,2,516
      • {SA}
      • FT-IR 1 (1), 457:B / FT-IR 2 (1), 726:A / FT-NMR 1 (1), 724:C / IR-Spectra (3), 270:G / IR-Spectra (2), 242:A / NMR-Reference 2 (1), 417:D / RegBook 1 (1), 501:L / Sax 6 , 1574 / Sigma FT-IR 1 (2), 157:B
        • 501-30-4 H72828 Kojic acid 曲酸

        化学属性

        Mol. FormulaC6H6O4
        Mol. Weight142.11
        Melting Point152-155°C
        TSCANo
        Solubility一种黑色素专属性抑制剂，溶于水，易溶于丙酮和乙醇，微溶于乙醚、乙酸乙酯、氯仿和吡啶；不溶于苯。
        Density1.542
        Boiling Point401.7°C at 760 mmHg

        *以上化合物性质及应用等信息仅供参考