Baicalein 黄芩素

规格: 98%
CAS: 491-67-8
产品编号: H64921
MDL: MFCD00017459
品牌: INFI
Chemical NameBaicalein
Synonym Baicalein {LY} Baicalein {} {LY} Baicalein {} {} {LY} Baicalein {} {} {} {LY} Baicalein {} {} {} {} {LY} Baicalein {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00017459
PubChem Substance ID5281605
Beilstein Registry Number272683
CAS Number491-67-8
Reaxys-RN272683
Merck Number942
Chemical Name Translation黄芩素
InChIInChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
LabNetwork Molecule IDLN00194973
Canonical SMILESO=C1C=C(C2=CC=CC=C2)OC3=CC(O)=C(O)C(O)=C13
GHS Symbol
WGK Germany3
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
    Hazard statements
    • H315 Causes skin irritation 会刺激皮肤
    • H319 Causes serious eye irritation 严重刺激眼睛
    • H335 May cause respiratory irritation 可能导致呼吸道刺激
      Hazard Codes Xi
      Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
      Signal word
      RTECSDJ3100898
      Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
      Safety Statements
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
      • S37 Wear suitable gloves 戴适当手套；
      • S36 Wear suitable protective clothing 穿戴适当的防护服；
        Risk Statements
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
        • An inhibitor of Ca2+ uptake, 5-LO, and 12-LO
        • {MCE} [2]. Patwardhan RS, et al. Baicalein exhibits anti-inflammatory effects via inhibition of NF-κB transactivation. Biochem Pharmacol. 2016 May 15;108:75-89.
        • {MCE} [3]. Ma X, et al. Baicalein suppresses metastasis of breast cancer cells by inhibiting EMT via downregulation of SATB1 and Wnt/β-catenin pathway.
        • {MCE} [4]. Kong EK, et al. A novel anti-fibrotic agent, baicalein, for the treatment of myocardial fibrosis in spontaneously hypertensiverats. Eur J Pharmacol. 2011 May 11;658(2-3):175-81.
        • {MCE} Drug Des Devel Ther. 2016 Apr 18;10:1419-41.
        • {MCE} Drug Des Devel Ther. 2016 Apr 18;10:1419-41.
        • {SA} Merck 14 ,942
        • {ALD} Merck: 14,942
        • {ALD} Merck: 14,942
        • Beilstein:18(5)4,569
        • {MCE} [1]. Shieh DE,et al. Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin. Anticancer Res. 2000 Sep-Oct
        • {MCE} [1]. Shieh DE,et al. Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin. Anticancer Res. 2000 Sep-Oct;20(5A):2861-5.
          • 491-67-8 H64921 Baicalein 黄芩素

          化学属性

          Mol. FormulaC15H10O5
          Mol. Weight270.24
          Melting Point256-271°C
          TSCANo
          Density1.548
          Appearance 黄色粉末，熔点264-265℃，溶于乙醇、甲醇、乙醚、丙酮、醋酸乙酯和热冰醋酸，微溶于氯仿和硝基苯，几乎不溶于水。溶于稀氢氧化钠呈绿棕色，溶于浓硫酸呈黄色并有绿色荧光。
          SolubilitySoluble in alcohol, methanol, ether, acetone, ethyl acetate, hot glacial acetic acid, dilute sodium hydroxide, and DMSO (50 mM). Insoluble in water
          Stability对光和热敏感
          Boiling Point650.2°C at 760 mmHg

          *以上化合物性质及应用等信息仅供参考