Eucalyptol 桉油精

规格: 99%
CAS: 470-82-6
产品编号: H64065
MDL: MFCD00167977
品牌: INFI
Chemical NameEucalyptol
CAS Number470-82-6
Synonym 1 1,3,3-Trimethyl-2-oxabicyclo(2.2.2)octane 1,3,3-trimethyl-2-oxabicyclo(2.2.2)octan 1,3,3-三甲基-2- 1,3,3-三甲基-2-氧杂二环[2.2.2]辛烷 1,3,3-三甲基-2-氧杂二环[2.2.2]辛烷 1,8-桉叶素 1,8-环氧对孟烷 桉叶油醇 1,8,8-trimethyl-7-oxabicyclo[2.2.2]octane 1,8-CINEOLE 1,8-Cineole-d3 1,8-cineol (eucalyptol) 1,8-cineole 1,8-cineole (Eucalyptol) 2-Oxa-1,3,3-trimethylbicyclo[2.2.2]octane 8-环氧对孟烷 CINEOLE-1,8 Eucalyptol, 1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane, 1,8-Cineole LABOTEST-BB LT00440774 Limonene oxide Terpan Zineol eucalyptol {} {} {uni_hambu {} {} {uni_hamburg 桉叶油醇 桉叶素,桉叶油醇; 桉树脑; 1,8-环氧对孟烷; 欧卡那卜托; 1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷 桉树脑 萜烷
PubChem Substance ID24893017
EC Number207-431-5
Beilstein Registry Number105109
MDL NumberMFCD00167977
Merck Number3895
Chemical Name Translation桉叶油素
Reaxys-RN105109
Wiswesser Line NotationT66 A B AOTJ B1 B1 F1
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2480 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - coma
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 2,327,1964

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2250 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   TFAKA4 Trudy Instituta Fiziologii, Akademiya Nauk Kazakhshoi SSR.
   Transactions of the Institute of Physiology, Academy of Sciences of the
   Kazakh. SSR.  (Izdatel'stvo Nauka Kazakhskoi SSR, Alma- Ata, USSR)  V.1-
   1955-  Volume(issue)/page/year: 1,134,1955

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1070 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   SIZSAR Sapporo Igaku Zasshi.  Sapporo Medical Journal.  (Sapporo Igaku
   Daigaku, Nishi-17-chome, Minami-1-jo, Chuo-ku, Sapporo 060, Japan)  V.3-
   1952-  Volume(issue)/page/year: 3,73,1952

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JSICAZ Journal of Scientific and Industrial Research, Secti

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 200 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   10(Suppl 10),1,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2 gm/kg
SEX/DURATION            : female 19-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   22,543,1973

WGK Germany2
Hazard Codes 3
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
    Signal word Warning
    RTECSOS9275000
    Packing GroupIII
    UN Number 1993 UN3271
    Risk Statements
    • R10 Flammable 易燃
      Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
      Safety Statements
      • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
      • S39 Wear eye/face protection 戴眼睛/面孔保护装置；
        Precautionary statements
        • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
        • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
        • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
        • P303+P361+P353
        • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
        • P370+P378
        • P403+P235
        • P501 Dispose of contents/container to..… 处理内容物/容器.....
          Hazard Class3
          Storage condition 2-8°C
          Warnings 危化品目录(2015)
          Restrict 危险品
        • The chief constituent of oil of eucalyptus. Used as pharmaceutic aid (flavor).
        • {MCE} [2]. Zeraatpisheh Z, et al. Eucalyptol induces hyperexcitability and epileptiform activity in snail neurons by inhibiting potassium channels. Eur J Pharmacol. 2015 Oct 5;764:70-8.
        • {MCE} [3]. Khan A, et al. 1,8-cineole (eucalyptol) mitigates inflammation in amyloid Beta toxicated PC12 cells: relevance to Alzheimer's disease. Neurochem Res. 2014 Feb;39(2):344-52.[3]
        • {MCE} [4]. Caldas GF, et al. Repeated-doses and reproductive toxicity studies of the monoterpene 1,8-cineole (eucalyptol) in Wistar rats. Food Chem Toxicol. 2016 Nov;97:297-306.
        • {TRC} Jori, et al.: Eur. J. Pharmacol., 9, 362 (1970),
        • {TRC} Maugh, T.H., Science, 218, 278 (1982),
        • {ALD} Merck: 14,3895
        • {ALD} Merck: 14,3895
        • Beilstein: 17,V,1,273
        • {uni_hamburg} Short: II/27B
        • {MCE} [1]. Jarvis GE, et al. Nonco
        • {MCE} [1]. Jarvis GE, et al. Noncompetitive Inhibition of 5-HT3 Receptors by Citral, Linalool, and Eucalyptol Revealed by Nonlinear Mixed-Effects Modeling. J Pharmacol Exp Ther. 2016 Mar;356(3):549-62.
          • 470-82-6 H64065 Eucalyptol 桉油精

          化学属性

          Mol. FormulaC10H18O
          Mol. Weight154
          Refractive indexn20/D 1.457(lit.)
          Boiling Point176-177
          Density0.921
          Melting Point1-2
          Flash Point48°C(lit.)
          TSCAYes
          Solubility微溶于水，可混溶于醇、氯仿、甘油。

          *以上化合物性质及应用等信息仅供参考