o-Phenylenediamine 邻苯二胺

规格: 99.5%
CAS: 95-54-5
产品编号: H54227
MDL: MFCD00007721
品牌: INFI
Chemical Name1,2-Phenylenediamine
CAS Number95-54-5
Synonym 1,2-Phenylenediamine {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {TRC} o-Phenylenediamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} o-Diaminobenzene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} o-Diaminobenzene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} o-Diaminobenzene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} o-Diaminobenzene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} o-Diaminobenzene
PubChem Substance ID7243
EC Number202-430-6
Beilstein Registry Number606074
MDL NumberMFCD00007721
Reaxys-RN606074
Merck Number7284
Chemical Name Translation1,2-苯二胺
Wiswesser Line NotationZR BZ
LabNetwork Molecule IDLN00194690
InChIInChI=1S/C6H8N2/c7-5-3-1-2-4-6(5)8/h1-4H,7-8H2
Canonical SMILESNC1=CC=CC=C1N
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 336 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 50(6),78,1985

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JTEHD6 Journal of Tox

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1873 mg/m3
TOXIC EFFECTS :
   Peripheral Ne

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85INA8 "Documentation of the Threshold Limit Values and Biological Exposure
   Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
   Industrial Hygienists, Inc., 1986  Volume(issue)/page/year: 6,1214,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KJMSAH Kyushu Journal of Medical Science.  (Fukuoka, Japan)  V.6-15,
   1955-64.  Discontinued.  Volume(issue)/page/year: 13,175,1962

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 umol/plate
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floo

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - hamster
DOSE/DURATION           : 432 mg/kg/24H
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   43,249,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 gm/L
REFERENCE :
   JIMMBG Journal of Immunological Methods.  (Elsevier Science Pub. Co., Inc.,
   52 Vanderbilt Ave., New York, NY 10017)  V.1-    1971-
   Volume(issue)/page/year: 36,55,1980

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - guinea pig
DOSE/DURATION           : 216 mg/kg/24H
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   43,249,1980

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 140 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 192,239,1987

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 216 mg/kg/24H
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl.

WGK Germany3
Hazard Codes T,N
Hazard statements
  • H302+H312
  • H312+H332
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H301 Toxic if swallowed 吞食有毒
  • H351 Suspected of causing cancer 怀疑致癌
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H332 Harmful if inhaled 吸入有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H371 May cause damage to organs 可能导致器官损伤
    Precautionary statements
    • P337+P313
    • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P305+P351+P338
    • P308+P313
    • P304+P340+P310
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
    • P301+P312+P330
    • P302+P350
    • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
    • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
    • P201 Obtain special instructions before use. 使用前获取专门指示。
    • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P273 Avoid release to the environment. 避免释放到环境中。
    • P305+P351+P338+P337+P313
    • P308+P311
    • P405 Store locked up. 上锁保管。
    • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
      Signal word
      RTECSSS7875000
      UN Number
      Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
      Safety Statements
      • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
      • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
      • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
      • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
      • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
        Risk Statements
        • R20/21 Harmful by inhalation and in contact with skin 吸入及与皮肤接触有害
        • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
        • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
        • R36 Irritating to eyes 刺激眼睛
        • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
        • R50/53
        • R25 Toxic if swallowed 吞咽有毒
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
          Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
          Packing GroupIII
          Hazard Class6.1
          Warnings 危化品目录(2015)
          Restrict 危险品
        • 检定镍和铌，分光光度法测定硒。钒的检定。从氮的氧化物和双氧水中分离臭氧。用以区别亚硝酸、过氧化氢与臭氧。酸碱滴定的荧光指示剂（pH≦3.1呈绿色荧光，pH≧4.4荧光消失）螯合沉淀剂。还原剂。
        • 邻苯二胺是一种过氧化物酶底物，适用于ELISA酶联反应。该底物产生一种可溶性的终端产品，为橙褐色，可以被分光光度计在450nm读取。该OPD 反应可以用3 N HCl 或 3 M H2SO4 终止并在 492 nm处读取。
        • {ALD} Merck: 14,7284
        • {ALD} Merck: 14,7284
        • Beilstein: 13,IV,38
        • {uni_hamburg} Short: II/27B
        • {TRC} Wu, Y. et al.: Anal. Bioanal. Chem., 400, 2141 (2011); Du, D. et al.: Anal. Chem., 82, 2989 (2010);
          • 95-54-5 H54227 o-Phenylenediamine 邻苯二胺

          化学属性

          Mol. FormulaC6H8N2
          Mol. Weight108
          Boiling Point256 - 258 °C
          Melting Point100 - 102 °C
          Density1.01
          Flash Point136 °C - 闭杯
          SolubilitySoluble in alcohol, chloroform, ether, slightly soluble in water
          TSCAYes
          Vapor Density3.7 (vs air)
          Vapor Pressure0.01 mmHg ( 25 °C)
          Stability对光敏感,对空气敏感
          Appearance tablet

          *以上化合物性质及应用等信息仅供参考