4-Aminopyridine 4-氨基吡啶

规格: 98%
CAS: 504-24-5
产品编号: H53369
MDL: MFCD00006439
品牌: INFI
Chemical Name4-Aminopyridine
CAS Number504-24-5
Synonym 4AP γ-Aminopyridine 4-氨基氮杂苯 EL 970 PYRIDIN-4-YLAMINE 4-pyridylamine Pyridine-4-ylamine 4-吡啶胺 4AP 对氨基吡啶 氨吡啶 4-pyridinamine avitrol Neurelan VMI 10-3 pyridin-4-amine Amino-4 pyridine 鸟安定 Prc 1237 2-氨基吡啶 α-吡啶胺 4-吡啶胺 Pimadin (free base) Γ-氨基吡啶 4APY gamma-Aminopyridine 对氨基吡啶 Avitrol; 4-Pyridinamine; 4-Pyridylamine; Amino-4-pyridine; gamma-Aminopyridine FAMPRIDINE 对氨基氮苯 Avitrol 4-aminopyridine Ampyra GAMMA-AMINOPYRIDINE ?-Aminop 4-氨基吡啶 pyridin-4-ylamin
PubChem Substance ID1727
EC Number207-987-9
Beilstein Registry Number105782
MDL NumberMFCD00006439
Merck Number14,3933
Chemical Name Translation4-氨基吡啶
Wiswesser Line NotationT6NJ DZ
LabNetwork Molecule IDLN00195685
Reaxys-RN105782
InChIInChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 19 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 57(9-10),64,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 19 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EKMMA8 Eksperimentalna Meditsina i Morfologiya.  (Hemus, Blvd. Russki 6,
   Sofia, Bulgaria) V.1-    1962-  Volume(issue)/page/year: 11,162,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 26,345,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 3700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   26,532,1973

TYPE OF TEST            : LD50

WGK Germany3
Hazard Codes T+,N T+,N,T,Xi T+
Hazard statements
  • H300 Fatal if swallowed 吞食致命
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
    Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
    RTECSUS1750000
    Precautionary statements
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P301+P310
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P305+P351+P338
      Signal word Danger
      Safety Statements
      • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
      • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
      • S1 Keep locked up 上锁；
      • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
      • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
      • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
      • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
      • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
        UN Number UN 2671 6.1/PG 2 UN2671 2671
        Risk Statements
        • R51/53
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
        • R28 Very toxic if swallowed 吞咽极毒
        • R24 Toxic in contact with skin 与皮肤接触有毒
          Packing GroupII
          Hazard Class6.1
          Storage condition 0-6°C
          Warnings 危化品目录(2015)
          Restrict 危险品
        • ########
        • {TRC} Judge S., et al.: Pharmacol. Ther., 111, 224 (2006),
        • {TRC} Wu, Z.Z., et al.: J. Biol. Chem., 284. 36453 (2009),
        • {SA}
        • Husch, A., et al., Calcium Current Diversity In Physiologically Different Local Interneuron Types Of The Antennal Lobe. J. Neurosci. 29 , 716-26, (2009) 摘要
        • {SA}
        • {SA} Pippow, A., et al., Differences of Ca2+ handling properties in identified central olfactory neurons of the antennal lobe. Cell Calcium 46 , 87-98, (2009) 摘要
        • {SA}
        • {SA} Merck 14 ,3933
        • {SA}
        • Beil. 22 ,V,9,106
        • {SA}
        • Aldrich MSDS 1 , 112:D / Corp MSDS 1 (1), 222:B / FT-IR 1 (2), 765:D / FT-IR 2 (3), 3753:B / FT-IR 1 (1), 765:D / FT-NMR 1 (3), 291:A / IR-Spectra (2), 1155:G / IR-Spectra (3), 1327:E / NMR-Reference 2 (2), 645:C / RegBook 1 (2), 2523:H / Sax 6 , 248 / Sigma FT-IR 1 (2), 280:D / Structure Index 1 , 398:E:3 / Vapor Phase 3 , 1536:C
        • {uni_hamburg} Short: II/14a
        • Title: Molecular Constants: Diamagnetic Molecules
        • Author: Demaison, J.; Dubrulle, A.; Hüttner, W.; Tiemann, E.
        • Editor: Hellwege, K.-H.; Hellwege, A.M.
        • Source: Landolt-Börnstein, New Series
        • Volume: II/14a
        • Page: 1-788
        • Year: 1982
        • Keyword: organic compounds; molecular constants; spectroscopy; microwave spectroscopy
        • ISBN: 3-540-11365-7
        • ISBN: 978-3-540-11365-2
        • Internet Resource: DOI:10.1007/b19966
        • RefComment: 196 figs., XI
        • {uni_hamburg} Short: III/20a
        • Title: Nuclear Quadrupole Resonance Spectroscopy Data: Nuclei D ... Cl
        • Author: Chihara, H.; Nakamura, N.
        • Editor: Hellwege, K.-H.; Hellwege, A.M.
        • Source: Landolt-Börnstein, New Series
        • Volume: III/20a
        • Year: 1988
        • Keyword: NQR
        • ISBN: 3-540-18161-X
        • ISBN: 978-3-540-18161-3
        • Internet Resource: DOI:10.1007/b31153
        • RefComment: IX,677 pages. Hardcover
        • Abstract: Nuclear Quadrupole Resonance Spectroscopy has become a standard method for structural research in molecular and solid state physics as well as for different branches of chemistry. The volumes cover data for more th
          • 504-24-5 H53369 4-Aminopyridine 4-氨基吡啶

          化学属性

          Mol. FormulaC5H6N2
          Mol. Weight94.11
          Boiling Point287°C(lit.)
          Melting Point157.0 to 162.0 deg-C
          Density1.26
          Flash Point164°(327°F)
          TSCAYes
          Solubility溶于水、乙醚、苯，易溶于乙醇。

          *以上化合物性质及应用等信息仅供参考