Choline chloride 氯化胆碱

规格: 98%
CAS: 67-48-1
产品编号: H51995
MDL: MFCD00011721
品牌: INFI
Chemical NameCholine Chloride
CAS Number67-48-1
Synonym Choline (chloride) {LY} Choline (chloride) {} {LY} Choline (chloride) {} {} {LY} Choline (chloride) {} {} {} {LY} Choline (chloride) {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {} {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Choline (chloride)
EC Number200-655-4
Beilstein Registry Number3563126
MDL NumberMFCD00011721
PubChem Substance ID6209
Merck Number2206
Reaxys-RN3563126
Chemical Name Translation氯化胆碱
Wiswesser Line NotationQ2K1&1&1 &Q &G
LabNetwork Molecule IDLN00196636
InChIInChI=1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1
Canonical SMILESOCC[N+](C)(C)C.[Cl-]
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3400 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - chromodacryorrhea
   Behavioral - excitement
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 58,87,1945

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 735 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 6,477,1914/1915

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 51,281,1942

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 53 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 500 ug/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7,1,1985

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 500 ug/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7,1,1985

Signal word
WGK Germany1
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
    Risk Statements
    • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
      Precautionary statements
      • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
      • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
      • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
      • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
      • P332+P313
      • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P305+P351+P338
      • P305+P351+P338+P337+P313
        Hazard statements
        • H315 Causes skin irritation 会刺激皮肤
        • H319 Causes serious eye irritation 严重刺激眼睛
        • H335 May cause respiratory irritation 可能导致呼吸道刺激
        • H303 May be harmfully swallowed 吞食可能有害
          RTECSKH2975000
          Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
          Storage condition Store at room temperature, keep dry and cool {LY} Store at room temperature, keep dry and cool {} {LY} Store at room temperature, keep dry and cool {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry an
          Hazard Codes Xi
        • Choline acetyltransferase substrate
        • A source of methyl groups for methyl-transfer reactions.
        • Biochem/physiol Actions Acyl group acceptor
        • {TRC} Hartung, C., et al.: Toxicol. Appl. Pharmacol., 12, 486 (1968),
        • {uni_hamburg} Short: III/31a
        • {uni_hamburg} Short: III/10a
        • {TRC} Sitaram, N., et al.: Life Sci., et al.: 22, 1555 (1978),
        • {ALD} Merck: 14,2206
        • Beilstein:4(2)722
        • {ALD} Merck: 14,2206
        • {uni_hamburg} Short: III/5a
          • 67-48-1 H51995 Choline chloride 氯化胆碱

          化学属性

          Mol. FormulaC5H14ClNO
          Mol. Weight139.62
          Density1.205
          Melting Point302-305 °C
          TSCAYes
          SolubilitySoluble in water (500 mg/ml), alcohol, ethanol (28 mg/ml at 25 °C), DMSO (28 mg/ml at 25 °C), and methanol.
          Appearance 白色吸湿性结晶，无味，有鱼腥臭。Mp240℃。10%水溶液pH5-6，在碱液中不稳定。本品易溶于水和乙醇，不溶于乙醚、石油醚、苯和二硫化碳。低毒，LD 50 (大鼠，经口)3400 mg/kg。
          Stability对湿度敏感

          *以上化合物性质及应用等信息仅供参考