D-Mannitol D-甘露糖醇

规格: 98%
CAS: 69-65-8
产品编号: H38117
MDL: MFCD00064287
品牌: INFI
Chemical NameD-Mannitol
CAS Number69-65-8
Synonym D-Mannitol {LY} D-Mannitol {} {LY} D-Mannitol {} {} {LY} D-Mannitol {} {} {} {LY} D-Mannitol {} {} {} {} {LY} D-Mannitol {} {} {} {} {} {LY} D-Mannitol {} {} {} {} {} {} {LY} D-Mannitol {} {} {} {} {} {} {} {LY} D-Mannitol {} {} {} {} {} {} {} {} {LY} D-Mannitol {} {} {} {} {} {} {} {} {} {LY} D-Mannitol {} {} {} {} {} {} {} {} {} {} {LY} D-Mannitol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Mannitol {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Mannitol {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Mannitol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Mannitol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Mannitol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Mannitol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Mannitol {} {} {} {} {} {} {} {} {} {} {} {} {}
Beilstein Registry Number1,534
MDL NumberMFCD00064287
EC Number200-711-8
PubChem Substance ID87572160
Reaxys-RN1721898
Merck Number5745
Chemical Name TranslationD-甘露糖醇
Wiswesser Line NotationQ1YQYQ 2 -BBAA -D
LabNetwork Molecule IDLN00191304
InChIInChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1
Canonical SMILESOC[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
GHS Symbol
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TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 14 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 35,98,1936

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 17143 mg/kg/2D-C
TOXIC EFFECTS :
   Vascular - BP elevation not characterized in autonomic section
   Gastrointestinal - nausea or vomiting
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   AIMDAP Archives of Internal Medicine.  (AMA, 535 N. Dearborn St., Chicago,
   IL 60610)  V.1-    1908-  Volume(issue)/page/year: 144,2053,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 13500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 32,1367,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7470 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 32,1367,1981

TYPE OF TEST            :

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 1 mol/L
REFERENCE :
   ARMKA7 Archiv fuer Mikrobiologie.  (Berlin, Fed. Rep. Ger.)  V.1-94,
   1930-73.  For publisher information, see AMICCW.  Volume(issue)/page/year:
   91,305,1973

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 50 mmol/L
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 79,1171,1982

WGK Germany2
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSOP2060000
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
    Signal word Warning
    Risk Statements
    • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
      Precautionary statements
        Storage condition 2-8°C {LY} 2-8°C Store at RT. {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C
      • 检定和测定硼和锗，生化研究，极谱分析硼，金属掩蔽剂，有机微量分析测定羟基的标准，肾功能检验，单倍体育种。在微生物学中：甘露醇是某些微生物的良好培养基。
      • {MCE} [2]. Nishiyama, A., et al., Mannitol lowers fat digestibility and body fat accumulation in both normal and cecectomized rats. J Nutr Sci Vitaminol (Tokyo), 2009. 55(3): p. 242-51.
      • {MCE} [3]. Hanieh, H. and E. Sakaguchi, Effect of D-mannitol on feed digestion and cecotrophic system in rabbits. Anim Sci J, 2009. 80(2): p. 157-62.
      • {TRC} Makkee, M., et al.: Chem. Commun., 930 (1980),
      • {ALD} Merck: 14,5745
      • {ALD} Merck: 14,5745
      • Beilstein:1,534
      • {TRC} Pigman, W., et al.: The Carbohydrates, 249 (1957),
      • {uni_hamburg} Short: II/27B
      • {uni_hamburg} Short: III/5a
      • {MCE} [1]. Tan, K., et al., The mannitol operon repressor MtlR belongs to a new class of transcription regulators in bacteria. J Biol Chem, 2009. 284(52): p. 36670-9.
      • {MCE} [1]. Tan, K., et al., The mannitol operon repressor MtlR belongs to a new class of transcription regulators in bacteria. J Biol Chem, 2009. 284(52): p. 36670-9.
      • {MCE} [2]. Nishiyama, A., et al., Mannitol lowers fat digestibility and body fat accumu
        • 69-65-8 H38117 D-Mannitol D-甘露糖醇

        化学属性

        Mol. FormulaC6H14O6
        Mol. Weight182.17
        Melting Point167-170 °C
        Density1.52
        TSCAYes
        Boiling Point295 °C at 760 mmHg
        SolubilitySoluble in water, alcohol, pyridine, aniline. Insoluble in ether
        Flash Point290-295°C/3.5mm
        Appearance -0.40°(10%水溶液)。吸湿性极小。水溶液稳定。对稀酸、稀碱稳定。不被空气中氧氧化。溶于水(5.6g/100ml，20℃)及甘油(5.5g/100m1)。略溶于乙醇(1.2g/100m1)。溶于热乙醇。几乎不溶于大多数其他常用有机溶剂。20％水溶液的pH值为5.5～6.5。 天然品广泛存在于植物的叶、茎、根等中，如海藻、柿饼表面的白粉即为甘露糖醇，在食用菌类、地衣类、元葱及胡萝卜等中含量亦较多。由木犀科植物花白蜡树(Fraxinus ornus)的树液(分泌物、干燥而得的甘露聚糖中含30%～50%甘露糖醇。 D 无色至白色针状或斜方柱状晶体或结晶性粉末。无臭，具有清凉甜味。甜度约为蔗糖的57%～72%。每g产生8.37J热量，约为葡萄糖的一半。含少量山梨糖醇。相对密度1.49。旋光率[α] 20

        *以上化合物性质及应用等信息仅供参考