Triethylamine 三乙胺

规格: 99%
CAS: 121-44-8
产品编号: H33496
MDL: MFCD00009051
品牌: INFI
Chemical NameTriethylamine
CAS Number121-44-8
PubChem Substance ID87576377
EC Number204-469-4
Beilstein Registry Number605283
MDL NumberMFCD00009051
Reaxys-RN605283
Merck Number9666
Synonym Trethylamine 三乙基胺; N,N-二乙基乙胺 TEA N,N,N-triethylamine 三乙胺, 99+% triethylamine triethylammoniumyl n,n-diethyl-ethanamin (Diethylamino)ethane TETN Triethylamine, Free Base (1.08217) N,N,N-Triethylamine ethanamine,n,n-diethyl- Trietilamina AKOS BBS-00004381 Ethanamine, N,N-diethyl- C6H15N (triethyl-amine) N,N-Diethylethylamin N,N-diethylethanamine; TETN ai3-15425 Triethylamin TRIETHYLAMINE triethyl-amine 三乙胺 121-01 [3,8] Diethylethanamine (C2H5)3N N,N-Diethylethanamin N,N-Diethylethanamine 三乙基胺 N,N -Diethylethanamine TEN LEDA HPLC三乙胺 Triäthylamin Triaethylamin Triethylamine N，N-二乙基乙胺 N,N-DIETHYLETHANAMINE 三乙胺 三乙基胺, N,N-二乙基乙胺 N,N-二乙基乙胺
Chemical Name Translation三乙胺
Wiswesser Line Notation2N2&2
LabNetwork Molecule IDLN00198128
InChIInChI=1S/C6H15N/c1-4-7(5-2)6-3/h4-6H2,1-3H3
GHS Symbol
TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1000 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 4,119,1951

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 12 mg/m3/11W-C
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - visual field changes
REFERENCE :
   IAEHDW International Archives of Occupational and Environmental Health.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.35-    1975-  Volume(issue)/page/year: 57,

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 570 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 4,119,1951

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 31,238,1968

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 1 mg/m3
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 36(11),9,1971

WGK Germany1
Hazard Codes 3 F,C
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H302 Harmful if swallowed 吞食有害
  • H302+H312+H332
  • H311+H331
  • H312 Harmful in contact with skin 皮肤接触有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H332 Harmful if inhaled 吸入有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
    Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
    RTECSYE0175000
    Precautionary statements
    • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
    • P233 Keep container tightly closed. ?保持容器密闭。
    • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
    • P241+P242+P243
    • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
    • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
    • P273 Avoid release to the environment. 避免释放到环境中。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P301+P330+P331
    • P301+P330+P331+P310
    • P303+P361+P353
    • P303+P361+P353+P310+P363
    • P304+P340+P310
    • P305+P351+P338
    • P305+P351+P338+P310
    • P308+P311
    • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
    • P370+P378
    • P403+P233
    • P405 Store locked up. 上锁保管。
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Danger
      UN Number 1296
      Risk Statements
      • R11 Highly flammable 非常易燃
      • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
      • R35 Causes severe burns 会导致严重灼伤
      • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
        Safety Statements
        • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
        • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
        • S29 Do not empty into drains 不要排入下水道；
        • S3 Keep in a cool place 保存在阴凉处；
        • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
        • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
        • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
          Packing GroupII
          Storage condition 2-8°C 密封阴凉避光保存。
          Hazard Class3/8
          Warnings 危化品目录(2015)
          Restrict 危险品
        • An amine commonly used in many synthesis pathways.
        • {ALF} The apparent base strength of triethylamine has been increased by its use in combination with certain metal salts, examined by Rathke. For the acylation of malonic esters with acyl chlorides, MgCl2 was found to be effective, whereas other metal salts had no effect: J. Org. Chem., 50, 2622 (1985); Synth. Commun., 15, 1039 (1985); Tetrahedron, 48, 9233 (1993). For the Horner-Wadsworth-Emmons olefination reaction, LiBr or LiCl gave the best results under most conditions, although Mg salts showed some effect; other metal salts were ineffective: J. Org. Chem., 50, 2624 (1985).
        • {uni_hamburg} Short: II/25D
        • {ALD} Merck: 14,9666
        • Beilstein:4,99
        • {ALF} Addition of triethylamine enables the reaction of Grignard reagents with esters to be interrupted at the ketone stage. Deuterium-labelling shows that this is caused by enolization of the ketone. Good yields are obtained unless the ester itself is readily enolized: Synthesis, 877 (1980).
        • {ALD} Merck: 14,9666
          • 121-44-8 H33496 Triethylamine 三乙胺

          化学属性

          Mol. FormulaC6H15N
          Mol. Weight101.19
          Refractive index1.3990 to 1.4030
          Boiling Point88.8 °C(lit.)
          Density0.7252
          Melting Point−118 - −112 °C(lit.)
          Flash Point-8°C(lit.)
          TSCAYes
          Autoignition Point593 °F
          Vapor Density3.5 (vs air)
          Vapor Pressure51.75 mmHg ( 20 °C)
          SolubilitySoluble in water (133 g/l), ether, and ethanol (0.1 ml/ml).
          Stability对光敏感
          Danger-Level甲类

          *以上化合物性质及应用等信息仅供参考