| Chemical Name | Diphenyl diselenide |
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| Synonym |
diphenylselenide
Bis(phenylselenide) |
| CAS Number | 1666-13-3 |
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| EC Number | 216-780-2 |
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| Beilstein Registry Number | 6,346 |
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| MDL Number | MFCD00003001 |
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| PubChem Substance ID | 15460 |
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| Chemical Name Translation | 二苯基二硒醚 |
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| Reaxys-RN | 2047179 |
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| InChIKey | YWWZCHLUQSHMCL-UHFFFAOYSA-N |
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| Wiswesser Line Notation | R-SE--SE-R |
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| LabNetwork Molecule ID | LN00197902 |
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| InChI | InChI=1S/C12H10Se2/c1-3-7-11(8-4-1)13-14-12-9-5-2-6-10-12/h1-10H |
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| Signal word |
|
GHS Symbol
| WGK Germany | 3 |
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| Safety Statements | |
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|
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| Risk Statements | |
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- R33 Danger of cumulative effects 有累积作用的危险
- R50/53
- R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
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| Precautionary statements | |
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- P301+P310
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P273 Avoid release to the environment. 避免释放到环境中。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
- P301+P310+P330
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P305+P351+P338
- P304+P340+P310
- P405 Store locked up. 上锁保管。
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
- P403+P233
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
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| Hazard statements | |
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- H300+H330
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- H301+H331
- H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
- H331 Toxic if inhaled 吸入中毒
- H301 Toxic if swallowed 吞食有毒
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| Personal Protective Equipment |
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| RTECS | JM9152500 |
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| Packing Group | II |
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| UN Number |
3283 |
| Hazard Codes |
T,N |
| Hazard Class | 6.1 |
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| Storage condition |
Store at 0-5°C |
| Warnings |
危化品目录(2015) |
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 28 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
Volume(issue)/page/year: NX#05657
| Restrict |
危险品 |
用于合成烯丙基醇、烯丙基醚、乙酸酯和α，β-不饱和羰基化合物。
{ALF} For introduction of the phenylseleno group by Michael addition, phenylselenol can be generated in situ by borohydride cleavage: Synthesis, 664 (1980).
{ALF} For a comprehensive review of the preparation of ɑß-unsaturated carbonyl compounds and nitriles by selenoxide elimination, see: Org. React., 44, 1 (1993). Compare also Phenyl­selenenyl­ bromide, A11906 and Phenyl­selenenyl­ chloride, A12751.
{ALF} Reagent for ɑ-phenylselenation of enolates. The products are readily oxidized to the selenoxides which undergo ambient temperature Cope-type elimination, providing a mild method for the introduction of ɑß-unsaturation into, e.g. ketones: J. Am. Chem. Soc., 97, 5434 (1975):
{uni_hamburg} Short: EINECS
{uni_hamburg} Short: III/5a
{ALD} Beilstein:6,346
{ALF} Oxidation of diphenyl diselenide by persulfate in the absence of a nucleophilic counter-ion generates the phenylselenium cation, which adds to alkenes. Molecules with a suitably placed nucleophilic site (alkene, hydroxyl, carbonyl, carboxyl, etc.) can then undergo intramolecular cyclization: J. Org. Chem., 55, 429 (1990); J. Chem. Soc. Perkin 1, 1989 (1993); Synlett, 373 (1994):
{uni_hamburg} Short: III/35G
{ALF} For reviews of the application of organoselenium reagents in organic synthesis, see: Tetrahedron, 34, 1049 (1978); Acc. Chem. Res., 12, 22 (1979); 17, 28 (1984). Monograph: Organoselenium Chemistry, D. Liotta, ed., Wiley, N.Y. (1987).
