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400-106-2016

N,N,N′,N′-Tetramethylethylenediamine 四甲基乙二胺

规格: 99%

CAS: 110-18-9

产品编号: H16830

MDL: MFCD00008335

品牌: INFI

Chemical Name	N,N,N',N'-Tetramethylethylenediamine
CAS Number	110-18-9
Alfabeta Name	TETRAMETHYLETHYLENEDIAMINE NNNN-,,,''
MDL Number	MFCD00008335
Synonym	N,N,N′,N′-Tetramethylethylenediamine, for electrophoresis, 99% {LY} N,N,N′,N′-Tetramethylethylenediamine, for electrophoresis, 99% {} {LY} N,N,N′,N′-Tetramethylethylenediamine, for electrophoresis, 99% {} {} {LY} N,N,N′,N′-Tetramethylethylenediamine, for electrophoresis, 99% {} {} {} {LY} N,N,N′,N′-Tetramethylethylenediamine, for electrophoresis, 99% {} {} {} {} {LY} N,N,N′,N′-Tetramethylethylenediamine, for electrophoresis, 99% {} {} {} {} {} {LY} N,N,N′,N′-Tetramethylethylenediamine, for electrophoresis, 99% {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,N,N′,N′-Tetramethylethylenediamine, for electrophoresis, 99% {} {} {} {} {} {} {} {LY} N,N,N′,N′-Tetramethylethylenediamine, for electrophoresis, 99% {} {} {} {} {} {} {} {} {LY} N,N,N′,N′-Tetramethylethylenediamine, for electrophoresis, 99% {} {} {} {} {} {} {} {} {} {LY} N,N,N′,N′-Tetramethylethylenediamine, for electrophoresis, 99% {} {} {} {} {} {} {} {} {} {} {LY} N,N,N′,N′-Tetramethylethylenediamine, for electrop
PubChem Substance ID	8037
EC Number	203-744-6
Beilstein Registry Number	1732991
Reaxys-RN	1732991
Merck Number	9134
Chemical Name Translation	N,N,N',N'-四甲基乙二胺
Wiswesser Line Notation	1N1&2N1&1
LabNetwork Molecule ID	LN00173973
InChI	InChI=1S/C6H16N2/c1-7(2)5-6-8(3)4/h5-6H2,1-4H3
Canonical SMILES	CN(C)CCN(C)C

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 268 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Spinal Cord - other degenerative changes
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 15,19,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1230 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 15,19,1995

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1318 ppm/4H
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - ataxia
   Behavioral - irritability
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 8,249,1988

TYPE OF TEST

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 630 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 28(6),55,1984

{hazard_

Warnings	危化品目录(2015) HYGROSCOPIC, FLAMMABLE
WGK Germany	1
Hazard statements
H225 Highly flammable liquid and vapour 高度易燃液体和蒸气 H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤 H332 Harmful if inhaled 吸入有害 H302 Harmful if swallowed 吞食有害
Personal Protective Equipment	Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes	3 F,C
RTECS	KV7175000
Precautionary statements
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。 P233 Keep container tightly closed. ?保持容器密闭。 P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。 P241+P242+P243 P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。 P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。 P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。 P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。 P301+P330+P331+P310 P303+P361+P353 P303+P361+P353+P310+P363 P304+P340+P310 P305+P351+P338 P305+P351+P338+P310 P308+P311 P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。 P403+P233 P405 Store locked up. 上锁保管。 P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word	Danger
UN Number	2372
Risk Statements
R11 Highly flammable 非常易燃 R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害 R34 Causes burns 会导致灼伤
Safety Statements
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟； S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见； S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护； S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Storage condition	Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {
Packing Group	II
Hazard Class	3
Restrict	-

TEMED 是用于催化过硫酸铵或核黄素形成自由基的叔胺基。自由基将引起丙烯酰胺和 N,N'-亚甲基双丙烯酰胺聚合形成可用于筛分大分子的凝胶基质。

{TRC} Bassam, B.J., et al.: BioTechniques, 19, 568 (1995),

{ALD} Merck:9134

Beilstein: 4,IV,1172

{ALF} The

{ALFA} The oxidative coupling of terminal acetylenes to diynes, by O2 in the presence of CuCl, is improved by addition

{TRC} Moham, D., et al.: J. Chromatogr., 979, 271 (2002),

{ALF} Used in combination with alkyllithiums in the ortho-metallation of aromatics; see, e.g.: Org. Synth. Coll., 6, 478 (1988); Org. Synth. Coll., 9, 559 (1998). For discussion of the dramatic acceleration of the rate of ortho-lithiation of anisole in the presence of TMEDA, effective also in sub-stoichiometric amounts, see: Tetrahedron Lett., 35, 385 (1994). See also Tetrahedron Lett., 35, 401 (1994), J. Org. Chem., 62, 3024 (1997) for further discussion of the role of TMEDA in ortho-metallation.

{ALF} Widely used complexing agent in lithiation reactions, often giving enhanced reactivity in otherwise difficult metallations: J. Am. Chem. Soc., 92, 4664 (1970). Subsequent work by Collum and others indicated that the situation may be much less straightforward than was previously thought, but the effect of TMEDA is likely to be most pronounced in the absence of strong donor solvents such as THF. For a discussion of the factors involved, see: Acc. Chem. Res., 25, 448 (1992). Under some conditions also, TMEDA itself may undergo lithiation: Organometallics, 13, 5173 (1994).

{ALF} In catalytic amounts, produces up to a 20-fold increase in reaction rate in aqueous Michael additions catalyzed by ytterbium triflate: J. Org. Chem., 71, 352 (2006).

{SA} Merck 14 ,9134

{ALD} Merck:9134

{ALF} The oxidative coupling of terminal acetylenes to diynes, by O2 in the presence of CuCl, is improved by addition of TMEDA as a complexing agent: J. Org. Chem., 27, 3320 (1962). For example and discussion, see: Org. Synth. Coll., 8, 63 (1993):

110-18-9 H16830 N,N,N′,N′-Tetramethylethylenediamine
四甲基乙二胺

化学属性

Mol. Formula	C6H16N2
Mol. Weight	116
Boiling Point	120 - 122 °C
Refractive index	1.4150 to 1.4190
Density	0.755
Melting Point	-55 ℃
Flash Point	20 °C
TSCA	Yes
Solubility	与水混溶，可混溶于乙醇、多数有机溶剂。
Stability	对光和湿度敏感
Danger-Level	甲类
pH	-:-
Redox	-

*以上化合物性质及应用等信息仅供参考