2-Iodoacetamide 2-碘乙酰胺

规格: 99%
CAS: 144-48-9
产品编号: H11544
MDL: MFCD00008028
品牌: INFI
Chemical Name2-Iodoacetamide
CAS Number144-48-9
PubChem Substance ID87571450
EC Number205-630-1
Beilstein Registry Number2(4)536
MDL NumberMFCD00008028
Synonym 2-Iodoacetamide {LY} 2-Iodoacetamide {} {LY} 2-Iodoacetamide {} {} {LY} 2-Iodoacetamide {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {} {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {}
Alfabeta NameIODOACETAMIDE 2-
Reaxys-RN1739080
Chemical Name Translation2-碘乙酰胺
Wiswesser Line NotationZV1I
LabNetwork Molecule IDLN00007307
InChIInChI=1S/C2H4INO/c3-1-2(4)5/h1H2,(H2,4,5)
Canonical SMILESO=C(N)CI
GHS Symbol
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1480 mg/kg/20W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   7,482,1953

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 74 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   47,179,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#02060

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 umol/L
REFERENCE :
   STBIBN Studia Biophysica.  (Akademie-Verlag GmbH, Postfach 1233, Berlin
   DDR-1086, Ger. Dem. Rep.) V.1-    1966-  Volume(issue)/page/year: 50,97,1975

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 20 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 24,365,1974

WGK Germany3
Hazard Codes T
Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H301 Toxic if swallowed 吞食有毒
  • H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
    Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
    RTECSAC4200000
    Precautionary statements
    • P301+P310
    • P342+P311
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P301+P310+P330
    • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
    • P305+P351+P338
    • P332+P313
    • P302+P352+P332+P313+P362+P364
    • P405 Store locked up. 上锁保管。
    • P305+P351+P338+P337+P313
    • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
      Signal word
      Safety Statements
        Risk Statements
        • R25 Toxic if swallowed 吞咽有毒
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
        • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
          Packing GroupIII
          UN Number UN 2811 6.1/PG 3 2811
          Storage condition 2-8°C, sealed storage, away from moisture and light {LY} 2-8°C, sealed storage, away from moisture and light Light Sensitive {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture
          Warnings IRRITANT
          Hazard Class6.1
        • 在蛋白组学中组氨酸和半胱氨酸的烷基化试剂，用于多肽测序以及酶抑制剂。也用于有机合成。
        • {SA}
        • 1. Gomi, T., and Fujioka, M., Inactivation of rat liver S-adenosylhomocysteinase by iodoacetamide Biochemistry 21 , 4171-4176, (1982) 摘要
        • {SA}
        • {SA} 2. Takahashi, K., The structure and function of ribonuclease T1. XXI. Modification of histidine residues in ribonuclease T1 with iodoacetamide J. Biochem. 80 , 1267-1275, (1976) 摘要
        • {SA}
        • {SA} Snider, J., et al., Formation of a Distinctive Complex between the Inducible Bacterial Lysine Decarboxylase and a Novel AAA+ ATPase J. Biol. Chem. 281 , 1532-46, (2006) 摘要
        • {SA}
        • {SA} Beil. 2 ,IV,536
        • {SA}
        • Aldrich MSDS 1 , 1089:C / Corp MSDS 1 (1), 1990:B / FT-IR 2 (1), 1259:C / FT-IR 1 (1), 751:B / IR-Spectra (2), 389:B / IR-Spectra (3), 439:C / NMR-Reference 2 (1), 632:C / RegBook 1 (1), 879:D / Sax 6 , 1617 / Sigma FT-IR 1 (2), 656:D / Structure Index 1 , 134:B:5
        • {uni_hamburg} Short: II/25B
        • Title: Structure Data Of Free Polyatomic Molecules: Molecules containing One or Two Carbon Atoms
        • Author: Graner, G.; Hirota, E.; Iijima, T.; Kuchitsu, K.; Ramsay, D.A.; Vogt, J.; Vogt, N.
        • Editor: Kuchitsu, K.
        • Source: Landolt-Börnstein, New Series
        • Volume: II/25B
        • Year: 1999
        • Keyword: Free Polyatomic Molecules; Carbon Atoms; Molecules
        • ISBN: 3-540-63645-5
        • ISBN: 978-3-540-63645-8
        • Internet Resource: DOI:10.1007/b68834
        • RefComment: IX, 512 pages. Hardcover
        • Abstract: Volume II/25 is a supplemented and revised edition of the preceding volumes II/7, II/15, II/21 and II/23 containing up to date information on inorganic and organic polyatomic molecules. All experimental methods for the determination of quantitative structural data of free molecules have been considered: microwave, infrared, Raman, electronic and photoelectron spectroscopy as well as electron diffraction. The data obtained by these methods have been critically evaluated and compiled. They are presented separately for each molecule, together with a schematic figure of the structure
          • 144-48-9 H11544 2-Iodoacetamide 2-碘乙酰胺

          化学属性

          Mol. FormulaC2H4INO
          Mol. Weight184.96
          Melting Point92-95°C
          Density2.278
          TSCAYes
          Solubility略溶于水
          Appearance crystalline 2-碘乙酰胺(144-48-9)为白色结晶。熔点95℃。溶于热水，易溶于乙醇。
          Stability光及湿度敏感
          Boiling Point297.1°C at 760 mmHg

          *以上化合物性质及应用等信息仅供参考